Making a tasty and juicy meatloaf doesn’t have to be intimidating. It’s an easy meal that can be prepared in different ways; baking your meatloaf at 375°F will help it cook evenly and ensure it comes out succulent and full of flavor, with the perfect “crust” on top. In this blog post, we’ll discuss how long to cook meatloaf at 375°F as well as some tips to make sure you get the best results every time! Read on for all the information you need to know about cooking delicious meatloaves.
Contents
- 1 What Is Meatloaf?
- 2 Is Meatloaf Goof For You?
- 3 Ingredients Needed To Cook Meatloaf
- 4 How To Cook Meatloaf At 375 From Scratch?
- 5 How Long To Cook Meatloaf At 375?
- 6 What Affect The Time To Cook Meatloaf?
- 7 What Temperature Should Meatloaf Be Cooked At?
- 8 Tips To Cook Meatloaf At 375 Perfectly
- 9 How Do I Know When A Meatloaf Is Cooked?
- 10 How To Keep Meatloaf Moist?
- 11 Should You Cook Meatloaf Covered Or Uncovered?
- 12 What Can I Put On Top Of Meatloaf?
- 13 What To Serve With Meatloaf?
- 14 Conclusion: How Long To Cook Meatloaf At 375?
- 15 FAQ: Cook Meatloaf At 375
- 15.1 Is it better to cook meatloaf at 350 or 375?
- 15.2 Should I cover meatloaf when baking?
- 15.3 How long do you cook a 2lb meatloaf at 375?
- 15.4 What is the perfect temperature for meatloaf?
- 15.5 What is the secret to moist meatloaf?
- 15.6 How do you not overcook meatloaf?
- 15.7 Why do you put milk in meatloaf?
- 15.8 How long to cook a 5 lb meatloaf at 375?
- 15.9 How long does it take to cook meatloaf at 400?
- 15.10 Can I cook meatloaf at 200 degrees?
- 15.11 What temp should meatloaf be cooked in Celsius?
- 15.12 What temp is meatloaf done in Celsius?
- 15.13 Is it OK if my meatloaf is a little pink?
- 15.14 Does meatloaf continue to cook while resting?
- 15.15 What ingredient keeps meatloaf from falling apart?
What Is Meatloaf?
Meatloaf is a traditional dish, usually made with ground beef or pork and mixed with various seasonings, vegetables, eggs, and breadcrumbs. It can be baked in the oven, fried on the stovetop, grilled outdoors, or even cooked in a slow cooker. No matter how you choose to make it, meatloaf usually has a savory flavor and moist texture.

Is Meatloaf Goof For You?
Meatloaf is a great choice for those looking to add more protein and iron into their diets. When prepared with lean meats, it can be a nutritious option as part of a balanced meal plan. As always, moderation is key when adding any type of food to your diet!
Ingredients Needed To Cook Meatloaf
The ingredients for a classic meatloaf include lean ground beef or pork, breadcrumbs, eggs, vegetables like onion and bell peppers, seasonings such as garlic powder and oregano, ketchup or barbecue sauce, salt, and pepper. Feel free to switch up the ingredients with different combos of your own choice!

How To Cook Meatloaf At 375 From Scratch?
Making meatloaf from scratch is incredibly easy!
All you need to do is mix together all of the ingredients, shape the mixture into a loaf and place it in an oven-safe baking dish.
Then bake it at 375°F for 1 hour and 15 minutes or until the internal temperature reaches 165°F.
Let the meatloaf rest for 10 minutes before serving.
How Long To Cook Meatloaf At 375?
When cooking your meatloaf in the oven, you should bake it at 375°F for about 45-60 minutes, depending on how large it is. If you’d like to double-check that it’s cooked through, use a meat thermometer to make sure the center has reached an internal temperature of 160°F. To ensure your meatloaf doesn’t dry out, you can cover it loosely with aluminum foil for the first half of the cooking time.
Watch this video to know how long to cook meatloaf at 375.
How Long To Cook A 4 Pound Meatloaf At 375?
A 4-pound meatloaf will take about 1 hour and 15 minutes to fully cook at 375°F. Again, you’ll want to use a thermometer and make sure the center has reached an internal temperature of 160°F before taking it out of the oven.
What Affect The Time To Cook Meatloaf?
The time it takes to cook your meatloaf will depend on how big and how dense the mixture is. For example, if you add more breadcrumbs or eggs to your recipe, these ingredients will help bind the mixture together and increase its overall density. This can affect how long it takes for the center of the loaf to reach an internal temperature of 160°F.
What Temperature Should Meatloaf Be Cooked At?
When cooking your meatloaf in the oven, you should bake it at 375°F for about 45-60 minutes, depending on how large it is. This temperature will ensure that the meat cooks evenly and stays moist.

Tips To Cook Meatloaf At 375 Perfectly
- Be sure to use lean ground beef or pork for the best flavor and texture.
- Don’t forget to season your meatloaf with herbs, spices, and sauces.
- If you’d like a crustier top, brush some ketchup or barbecue sauce on top before baking.
- Always remember to let the loaf rest for 10 minutes before slicing and serving.
- If you’re baking a large meatloaf, you may need to increase the cooking time by 15 minutes or so.
- To check for doneness, insert a thermometer into the center of the meatloaf and make sure it reaches an internal temperature of 160°F.
With these tips and tricks, you can now make the perfect meatloaf every time! Just keep in mind how long to cook it at 375°F, adjust the cooking time as needed for larger loaves, and use a thermometer to make sure your meatloaf has reached the proper temperature before serving.
How Do I Know When A Meatloaf Is Cooked?
The best way to determine when your meatloaf is done cooking is by using a meat thermometer. Insert the thermometer into the center of the loaf and make sure it reaches an internal temperature of 160°F before you take it out of the oven. This will ensure that your meatloaf is cooked through and safe to eat.
How To Keep Meatloaf Moist?
There are several ways to keep your meatloaf moist and flavorful.
First of all, make sure to use lean ground beef or pork for the best flavor and texture.
Also, adding some moisture-rich ingredients like diced onion, bell peppers, egg, breadcrumbs, and ketchup can help ensure your meatloaf stays juicy while it cooks.
Finally, it’s important to let the meatloaf rest for 10 minutes after baking so that all of the juices can settle back in.
Following these simple tips will guarantee moist and delicious meatloaf every time you make it!

Should You Cook Meatloaf Covered Or Uncovered?
When baking a meatloaf, you can cover it loosely with aluminum foil for the first half of the cooking time. This will help to keep the moisture in and prevent it from drying out while it cooks.
Once the internal temperature of your meatloaf has reached 160°F, you can remove the foil and let it finish baking uncovered. This will give it a nice golden brown color on top and make sure the flavor is locked in.
Follow these tips and you’ll be sure to get perfectly cooked meatloaf every time!
What Can I Put On Top Of Meatloaf?
There are lots of delicious options to top your meatloaf! Some popular choices include ketchup, barbecue sauce, diced onions, bacon bits, and cheese. You can also mix in some herbs and spices like garlic powder, oregano, and paprika for extra flavor.
Get creative with how you dress up your meatloaf and you’ll be sure to impress your guests with a delicious dinner every time!
What To Serve With Meatloaf?
Meatloaf is a favorite comfort food that pairs perfectly with all kinds of sides. Some classic side dishes to serve with meatloaf include mashed potatoes, roasted vegetables, steamed green beans, coleslaw, and macaroni and cheese. For a light and healthy meal that still hits all the right notes, add a fresh salad or roasted vegetables to your plate.
No matter how you dress it up, meatloaf always makes for a delicious and satisfying meal!

Conclusion: How Long To Cook Meatloaf At 375?
Now you know how long cook meatloaf at 375 and how to use a thermometer for accuracy. You also have plenty of ideas on how to dress up your meatloaf, as well as side dish options to serve with it. With these tips and tricks, you’ll be sure to create the ultimate comfort food every time! Thanks for reading at mollysmtview!
FAQ: Cook Meatloaf At 375
Is it better to cook meatloaf at 350 or 375?
If you’re interested in cooking up a delicious meatloaf, the temperature to set your oven at is 350 degrees F. This prevents it from drying out and ensures an optimal flavor experience!
Should I cover meatloaf when baking?
If you want a succulent and juicy meatloaf, it’s best to cook it uncovered. However, if you’re worried about the top getting too browned or burning, cover your masterpiece with foil for 45 minutes before revealing in all its golden glory. Then finish up by baking uncovered for 15 more minutes so that the top of your creation can develop some beautiful color!
How long do you cook a 2lb meatloaf at 375?
To achieve the perfect meatloaf, it is essential to understand how long one should cook the dish. A 1-pound loaf requires 35-45 minutes of baking time and a 2-pounder will take around an hour – but for those really hungry mouths, 3 pounds warrants 1 ½ to 2 hours in the oven! Bon Appétit!
What is the perfect temperature for meatloaf?
Cooking the perfect meatloaf requires precision. Your thermometer should read 160°F for a fully-cooked center, or try an oven-safe thermometer to track progress during baking!
What is the secret to moist meatloaf?
Unlock the secret to a succulent meatloaf by infusing flavor and juicy goodness into each step of your recipe. From eggs and ketchup to tomato paste, mustard, Worcestershire sauce or even barbecue – all that moisture will make it hard not to love!
How do you not overcook meatloaf?
For the perfect meatloaf, low and slow is key! According to cooking expert Alton Brown, 325F is ideal for a juicy loaf. Crank up your oven too high, though? Your overall result may be drier than desired – so keep that temperature in check for succulent results every time.
Why do you put milk in meatloaf?
Adding milk to meatloaf is a great way of ensuring that it stays moist and delicious. If you’re looking for alternatives, try low-sodium beef stock, chicken stock or even non-dairy milk substitutes!
How long to cook a 5 lb meatloaf at 375?
Bake your five-pound meatloaf in a preheated oven of 375 F to ensure juicy flavor and succulent texture. Cook for roughly 175 minutes, checking near the end that it reaches an internal temperature of 160°F.
How long does it take to cook meatloaf at 400?
Preparing a delicious, juicy meatloaf is easier than you think – just preheat your oven to 400 degrees F and bake for 45-50 minutes. Once the internal temperature reads 165, let it rest before slicing into that savory masterpiece! Enjoy this American favorite in under an hour with minimal effort on your part.
Can I cook meatloaf at 200 degrees?
For a delicious and flavorful meatloaf, cover the grill to create indirect heat as close to 200 degrees Fahrenheit. Keep an eye on it with an instant-read thermometer until its interior hits 140F for a perfectly cooked dinner!
What temp should meatloaf be cooked in Celsius?
To get the full, juicy flavor of meatloaf all the way through, aim for an internal temperature of 160 degrees Fahrenheit (70 Celsius). With that perfect cooking temp, your taste buds will thank you later!
What temp is meatloaf done in Celsius?
Enjoying a delicious, comforting meal of meatloaf tonight is easy – just remember to season your loaf and add any desired veggie ingredients before baking. Use an accurate thermometer throughout the cooking process for best results, including ensuring it’s cooked through at 160°F (71°C). Bon appétit!
Is it OK if my meatloaf is a little pink?
Won’t it be amazing, when your ground beef patty or meatloaf reaches the safe temperature of 160 F (71 C) despite its slightly pink appearance? Don’t rely on color alone to tell you how done it is – stay safe and make sure you cook through!
Does meatloaf continue to cook while resting?
A true test of culinary prowess, the art of cooking a perfect meatloaf requires more than just initial oven heat! During its resting period after removal from the oven, your dish will continue to cook internally due to ‘carryover cooking’, with an estimated rise in temperature up to 5 degrees – giving you that classic piping hot and juicy treat everyone knows and loves.
What ingredient keeps meatloaf from falling apart?
To prevent your meatloaf from turning into a pile of mush, don’t forget to include the essential binding agents – eggs and breadcrumbs. These key ingredients will help hold everything together as it cooks so you can enjoy your delicious creation in all its perfect form!

Bobby Kelly is a bartender at Molly Magees, an Irish pub in Mountain View. He’s been working there for two years and has developed a following among the regulars. Bobby is known for his friendly demeanor and great drink specials. He loves interacting with customers and making them feel welcome. When he’s not at work, Bobby enjoys spending time with his friends and family.